| Bioactivity | [Des-Arg9]-Bradykinin acetate is a Bradykinin B1 receptor agonist that displays selectivity for B1 over B2 receptors. | ||||||
| Target | Bradykinin B1 receptor | ||||||
| Invitro | [Des-Arg9]-Bradykinin acetate is a Bradykinin(B1) receptor agonist. The B2 receptor mediates the action of bradykinin (BK) and lysyl-bradykinin (Lys-BK), the first set of bioactive kinins formed in response to injury from kininogen precursors through the actions of plasma and tissue kallikreins, whereas the B1 receptor mediates the action of [Des-Arg9]-Bradykinin (des-Arg9-BK) and Lys-des-Arg Arg9-BK, the second set of bioactive kinins formed through the actions of carboxypeptidases on BK and Lys-BK, respectively[1]. | ||||||
| Name | [Des-Arg9]-Bradykinin acetate | ||||||
| CAS | 23827-91-0 | ||||||
| Sequence | Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe | ||||||
| Shortening | RPPGFSPF | ||||||
| Formula | C46H65N11O12 | ||||||
| Molar Mass | 964.07 | ||||||
| Appearance | Solid | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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| Reference | [1]. Leeb-Lundberg LM, et al. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol Rev. 2005 Mar;57(1):27-77. |
[Des-Arg9]-Bradykinin acetate
CAS: 23827-91-0 F: C46H65N11O12 W: 964.07
-Bradykinin acetate is a Bradykinin B1 receptor agonist that displays selectivity for B1 over B2 receptors.
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